Tip of the month – Juin 2026

par João Barbosa Breda | 19 Juin 2026 | Revue de presse

Considérer les sources de biais lors de l’utilisation de l’angiographie OCT

Principes scientifiques

L’angiographie OCT (OCTA) suscite un vif intérêt pour le diagnostic (1, 2) et le suivi (3) du glaucome. Cependant, plusieurs affections et maladies peuvent influencer ses résultats et doivent être prises en compte, notamment lors d’analyses longitudinales (4). Les maladies systémiques suivantes ont été identifiées comme sources potentielles de biais (même en l’absence de modifications visibles du fond d’œil) : hypertension artérielle, diabète, maladie coronarienne, sténose carotidienne, insuffisance rénale chronique (y compris l’hémodialyse), syndrome d’apnées obstructives du sommeil et plusieurs maladies neurodégénératives, telles que la maladie d’Alzheimer, la sclérose en plaques et la maladie de Parkinson (5). Globalement, ces maladies entraînent une diminution de la densité vasculaire (DV) et une augmentation de la surface et du périmètre de la zone avasculaire centrale (ZAC). D’autres facteurs, comme la pratique régulière d’exercices fractionnés de haute intensité (diminution de la DV) ou la grossesse (augmentation de la DV), peuvent également influencer les résultats. De nombreuses études publiées sur ce sujet n’ont pas tenu compte des facteurs de confusion pertinents, et il conviendrait d’améliorer ce point dans les études futures.

Références

Van Melkebeke L, Barbosa-Breda J, Huygens M, Stalmans I. OpBcal Coherence Tomography Angiography in Glaucoma: A Review. Ophthalmic Res. 2018:1-13.
Miguel AIM, Silva AB, Azevedo LF. DiagnosBc performance of opBcal coherence tomography angiography in glaucoma: a systemaBc review and meta-analysis. The BriBsh journal of ophthalmology. 2019;103(11):1677-84.
Miguel A, Silva A, Barbosa-Breda J, Azevedo L, Abdulrahman A, Hereth E, et al. OCTangiography detects longitudinal microvascular changes in glaucoma: a systemaBc review. The BriBsh journal of ophthalmology. 2022;106(5):667-75.
Monteiro-Henriques I, Rocha-Sousa A, Barbosa-Breda J. OpBcal coherence tomography angiography changes in cardiovascular systemic diseases and risk factors: A Review. Acta ophthalmologica. 2022;100(1):e1-e15.
Tsokolas G, Tsaousis KT, Diakonis VF, Matsou A, Tyradellis S. OpBcal Coherence Tomography Angiography in NeurodegeneraBve Diseases: A Review. Eye Brain. 2020;12:73- 87.

Tip publié en octobre 2023 : https://www.eugs.org/news/consider-sources-of-bias-when-using-oct-angiography-2023-10-15-tip-of-the-month

Traduction française : Philippe DENIS, Lyon

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